Bioactive Surfaces

FOR THE SUCCESS OF MEDICAL PRODUCTS AND TECHNOLOGIES

The performance and safety of established and new medical technologies strongly depend on the functionality of the materials used, and in particular on their surfaces. Minimizing undesired bioadhesion phenomena (colonization of microorganisms [fouling], activation of blood cells) via protein-phobic coatings and the selective stimulation of molecular and cellular interactions with surfaces and the release of biological substances are crucial for the success of medical products and technologies (e.g., cardiovascular implants, neurostimulatory electrodes, sensors, and organ replacement systems). Cross-application methods include the monitoring of blood coagulation and the immune response to the exposure of biomaterials; they are important goals that can be achieved via biological surfaces. Novel functionalization concepts use adaptable release systems that allow the appropriate dosage of active agents.